All a vaccine needs to do is show the immune system a Monty python abbey road shirt antigen. Your immune system doesn’t know or care really how that antigen got there, just that it wants to kill it right now. That’s what’s being referred to as “receptors of the virus’ own spike protein”. That’s receptors on cells that mediate the immune system response and decide if it needs to murder itFor COVID, the spike protein is the antigen of choice. Pfizer and Moderna use mRNA suspended lipid so your cells will take it in and manufacture that spike protein to trigger your immune system. The Johnson & Johnson vaccine uses a modified adenovirus that’s been rendered incapable of replication and just makes your cells produce those spike proteins. In this it’s a protein subunit vaccine, and they seem to have modified yeast to produce the spike protein which they tend extract to produce the vaccine.iirc this is the same kind of vaccine (or very similar_ as is used for Hep B. So it may have the same downside as that, where you need 3-4 doses for long term immunity.Immediately after the Cuban Revolution, Castro went on a speaking tour of the US, where he was wildly popular. He wanted trade with the US and promised to respect property ownership (with some exceptions like telco, which he felt were important for self-defense).Allan Dulles (CIA) recommended instead that a blockade be continued against Cuba. The rationale was, with all other doors closed, this would force Castro into the Soviet orbit (he had wanted Cuba to remain unaligned and unentangled). This would allow the US to paint Castro as a Soviet proxy and destroy his reputation with the US public, clearing the way for a counter-revolution.The Dulles brothers had previously accomplished something similar in Cuba in the 30’s. They used the US Navy to help overturn a Cuban election, in favor of their corporate backers.When countries end up at an extremist place, it’s often because their previous attempts to achieve respect and dignity have been pissed on and ignored.
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The fact that there are so many efforts in parallel us why it doesn’t make a ton if sense to ‘wait for the Monty python abbey road shirt like some people imagine. We are effectively on what would have been the seventh or eighth generation vaccine if the work had all been serialized at one company or university. We would have started with the most mature technology, rolled it out, then tested another option. That would have been disappointing, so we would try a third technique, etc. Since everybody was working at once, some companies were starting out by working on technology that would have been low on the list of things to try.Honestly, I was super skeptical that the mRNA technology would work as well as they hyped it. But the proof was in the pudding, and they proved it worked really well and made it at industrial scale before the older protein vaccine tech could do the same. If we had to pick just one project to fund in early 2020, we might not have a good vaccine yet, and the mRNA vaccines might still be years away waiting for R and D funding.