Glioblastoma (GBM). GBM is the most Yukon Jack Ugly Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

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If you happened to have called a Muslim, Jew, Atheist, etc…you may have caught them off-guard. However, unless they’re extremists or insanely liberal (aka progressive) it would be unlikely that they would be offended in any way. If any of the Yukon Jack Ugly Sweater before mentioned were offended or even “triggered” (for the far-left), you didn’t say anything that could or would be construed as an insult or inappropriate enough to pursue any charges with. That’s assuming that you’re relating “bad” to ‘illegal’ or ‘rude’. If you’re thinking more in line with Michael Jackson’s “Bad” then…well …it’s not really that either.

Christmas decorations are a Yukon Jack Ugly Sweater affectation. Whether one puts them up or doesn’t put them up, whether one leaves them up or takes them down, whether they are put up in January or any other time before December, has no impact on the superstition defined as luck. Good luck and bad luck are merely characterizations of serendipitous occurrences that are random in nature but which leave us either going hooray (good luck) or lamenting the vagaries of uncaring nature (bad luck). But worrying about or praying about or hoping for either as the case may be, like astrology for example, is simply superstitious dreck. As a native yo the city I must say there are three a places that I would suggest to visitors to really get the best holiday scene amd spirit. My first pick is going to be Westfield Mall’s extended outdoor shopping area Union Square. Located at the corner of Powell and Geary in the heart of downtown San Francisco the Christmas spirit is reminiscent of the movie “A Miracle on 24th Street”. That is minus the snow.