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Glioblastoma (GBM). GBM is the most Paddys Irish Whiskey Ugly Christmas Sweater 2023 Christmas Gift 3D Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

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One interesting facet of the NFL is that it’s effectively a Paddys Irish Whiskey Ugly Christmas Sweater 2023 Christmas Gift 3D Sweater layer professional sport with a set number of teams. There is no “second tier” from which teams are promoted to it — the line between pro and amatuer is pretty much absolute from what I can tell. Although there is a small “international pathway” academy, the main route into the NFL is through the college draft — drafted players become either part of the 52 man squad that plays, or part of the large reserve squad that is retained to provide training opposition, or they are not in the loop.

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