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Glioblastoma (GBM). GBM is the most OGC Nice Ugly Christmas Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

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One interesting facet of the NFL is that it’s effectively a OGC Nice Ugly Christmas Sweater layer professional sport with a set number of teams. There is no “second tier” from which teams are promoted to it — the line between pro and amatuer is pretty much absolute from what I can tell. Although there is a small “international pathway” academy, the main route into the NFL is through the college draft — drafted players become either part of the 52 man squad that plays, or part of the large reserve squad that is retained to provide training opposition, or they are not in the loop.

I would suggest that spending more often than not leads to the OGC Nice Ugly Christmas Sweater of wealth, either by paying for goods expected to be sold right away, or in anticipation of sales in the future Either way, for the most part those things sold will not be produced or cared for if someone wasn’t going to buy them. Whether perishable items, most of which help preserve some more durable form of wealth, like human capital, for instance. Or durable forms of wealth are produced that will last beyond the current time period. It is the “spending” that encourages the increased production and preservation of wealth. So whether you spend it or not, in terms of money you will have the same amount of money at the end of the given time period. which we can refer to as savings.