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Glioblastoma (GBM). GBM is the most Merry Hitsmas Santa Ugly Christmas Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

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Who was the worst coach in NFL history? When discussing the worst coaches in NFL history, assuming you’re only referring to head coaching duties, names like Rod Marinelli, Dave Shula, Lou Holtz, and Lane Kiffin are often bandied about, amongst others. These characters represent two major categories of Merry Hitsmas Santa Ugly Christmas Sweater professional coaching careers; the highly-regarded NFL assistant who couldn’t hack it as a head coach (Gus Bradley, Kevin Gilbride, etc.), and the successful college coach who was unable to transition into coaching multimillionaires (Spurrier, Saban, et al.). In defense of the first four coaches mentioned above, all of them inherited horrible teams. But a few coaches have taken on decently successful franchises, yet completely failed during their fleeting NFL careers.

I like to get this major sh**fight out of the way before I have to focus on other things, like making sure I’ve bought (and wrapped, in secret while everyone’s asleep) all the Merry Hitsmas Santa Ugly Christmas Sweater , then preparing for the feast, making all arrangements, buying food while battling snarling sweat-demons at the supermarket. It will be even more fun this year, with “social-distancing” at peak-pre-Christmastime. Wonder what that’s gonna look like? Our family have always had a slight (very slight) advantage of having Christmas one day earlier than most Australians. However, if we’re doing it this year, we’re staggering it. Maybe it’s time more people did. Our Christmas will be about a week early. This avoids the mass-hysteria grocery shopping, it will be one week less hot (temps go crazy on Christmas Day), and we can relax after, while everyone else is still stressed and suffering. I’ve talked my family into it. In previous years, there was some resistance, as it wasn’t “real Christmas time”. But “Christmastime” is just an idea in our heads, and no day is really any different to another. Christ wasn’t even born on December 25. And he’s not complaining that people changed his day to a time that was more convenient, so why should anyone complain about a re-change? Anyway, sorry, my main answer is “Yes, we can absolutely put up our dex early, because Christmas preps are such a nightmare, that I want to get a full two months mileage out of them before I have to take them down again in the new year.”