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Glioblastoma (GBM). GBM is the most Captain America Costume Ugly Xmas Wool Knitted Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

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Who was the worst coach in NFL history? When discussing the worst coaches in NFL history, assuming you’re only referring to head coaching duties, names like Rod Marinelli, Dave Shula, Lou Holtz, and Lane Kiffin are often bandied about, amongst others. These characters represent two major categories of Captain America Costume Ugly Xmas Wool Knitted Sweater professional coaching careers; the highly-regarded NFL assistant who couldn’t hack it as a head coach (Gus Bradley, Kevin Gilbride, etc.), and the successful college coach who was unable to transition into coaching multimillionaires (Spurrier, Saban, et al.). In defense of the first four coaches mentioned above, all of them inherited horrible teams. But a few coaches have taken on decently successful franchises, yet completely failed during their fleeting NFL careers.

Christmas begins at midnight on the Captain America Costume Ugly Xmas Wool Knitted Sweater of 24 December (the beginning of 25 December). One should not begin putting Christmas decorations up until Christmas Eve. Christmas Day lasts a full eight days, and ends on the first of January – the Octave Day of Christmas. The season of Christmas lasts until Epiphany on the 6 of January, so your decorations should stay up[ that long, and the Christmas Marian antiphon gets sung until the first of February, so you may take your Christmas decorations down at the end of January. Please, please, please do NOT put Christmas decorations up during Advent. Advent is the Penitential season which encompasses the four Sundays before Christmas, so it begins right around the end of November. To repeat, Advent is a PENITENTIAL season, so nothing of Christmas should intrude on Advent other than preparation – spiritual preparation for Christmas, going to confession each Saturday, saying extra prayers, going to daily Mass, etc. All would be excellent preparations for Christmas, but do NOT start celebrating Christmas itself until midnight at the beginning of 25 December!